Issue #92: The Gut-Brain Axis - Optimizing Nutrition for Cognitive and Emotional Well-being Post-Stroke.

The Hidden Power of Your Gut: Supporting YOUR Brain Health Through Diet After Stroke

Hey Warriors! Welcome back to Chuck's Stroke Warrior Newsletter

This week, we're diving deep (but not too deep!) into something called the gut-brain axis. Sounds complicated, right? Well, it's basically the superhighway that connects your tummy to your brain. And guess what? After a stroke, keeping this highway in tip-top shape is essential for your cognitive and emotional recovery. So, let's explore how optimizing your nutrition can make a HUGE difference. Let’s find out how to ensure a healthy and happy you, together!

đź§  Why Your Gut Might Be Sabotaging Your Stroke Recovery


You’re eating right. Doing therapy. But your brain still feels foggy. Your mood’s all over the place.


It’s not just “in your head.” A damaged gut can feed brain fog, depression, and slow healing. After a stroke, your gut microbiome—the bacteria that help your body function—can spiral out of balance. When this happens, your brain suffers. Memory slips. Anxiety creeps in. Motivation disappears. Recovery stalls.


Good news: You can reset the balance. Supporting your gut-brain axis with simple nutrition changes—like adding fermented foods, fiber, and omega-3s—can brighten your mood, boost focus, and speed up brain healing. This isn’t a trendy diet. It’s a game plan for mental clarity, emotional balance, and full-body recovery.

👉 Discover how food can heal from the inside out in our latest article: “The Gut-Brain Axis: Optimizing Nutrition for Cognitive and Emotional Well-being Post-Stroke.”

Updates and Recent Developments: Gut-Brain Connection Gets Serious

Gut-Brain Connection Gets Serious

Recent research is making it clearer than ever: what you eat impacts your brain health, especially after a stroke. Here's a quick rundown of some exciting developments:

The Microbiome's Mighty Influence

Claim: Gut bacteria influence brain inflammation, neurotransmitter production (like serotonin), and neuroplasticity, impacting stroke recovery.

Verification:

  • Recent research confirms that the gut microbiome directly influences brain inflammation after stroke, affecting both recovery and the risk of secondary injury. Gut-derived ligands are essential in regulating neuroinflammation, and restoring gut balance post-stroke can reduce neuroinflammation and potentially improve cognitive outcomes[1].

  • The gut-brain axis enables bidirectional communication, influencing immune responses, metabolism, and nervous system development. Post-stroke, gut dysbiosis can worsen outcomes by increasing inflammation and weakening the intestinal barrier[4].

  • Animal studies highlight that short-chain fatty acids (SCFAs), produced by gut bacteria, promote neuroplasticity and aid in stroke recovery[7].

Key Article:

Probiotics and Post-Stroke Improvement

Claim: Preliminary studies suggest probiotics may improve cognitive function and reduce anxiety in stroke survivors, but more research is needed.

Verification:

  • Meta-analyses and animal studies indicate that probiotics can reduce neurological deficits, decrease cerebral volume loss, and lower inflammation in stroke models. However, most evidence is preclinical, and further research is needed to confirm benefits and optimal strains/dosages in humans[2].

  • Probiotics show anti-inflammatory and anti-oxidative properties, but clinical recommendations require more robust data[2].

Key Article:

Dietary Patterns and Brain Health

Claim: The Mediterranean diet supports brain health, stroke prevention, and potentially recovery.

Verification:

  • A 2025 study found that adherence to a Mediterranean-style diet improved white matter integrity in the brain and reduced structural damage, supporting its role in stroke prevention and possibly aiding recovery. Benefits are linked to reduced inflammation, oxidative stress, and vascular health[3].

  • The American Heart Association recommends the Mediterranean diet for brain health and stroke prevention[3].

Key Article:

Inflammation is the Enemy

Claim: Foods that reduce inflammation in the gut and brain are linked to better outcomes, while pro-inflammatory foods are linked to worse outcomes.

Verification:

  • Multiple studies confirm that gut and brain inflammation are closely linked, and that anti-inflammatory dietary patterns (like the Mediterranean diet) are associated with better brain health and outcomes after stroke[1][3][4].

  • The gut contains the majority of the body's immune cells, and post-stroke inflammation can worsen prognosis[4].

Key Article:

New Therapeutic Approaches (FMT)

Claim: Fecal microbiota transplantation (FMT) is being explored to improve stroke outcomes, but is still experimental.

Verification:

  • Systematic reviews of preclinical studies show that FMT can improve neurological and behavioral outcomes after stroke by modulating the gut microbiota. However, these findings are mostly from animal studies, and FMT is not yet a standard treatment for stroke in humans[5][7].

  • Manipulating the gut microbiome via FMT is a promising but experimental approach[5].

Key Article:

Emerging Technologies

Claim: Advanced AI and genetic tools allow detailed analysis of the microbiota, improving understanding of gut-brain interactions.

Verification:

  • AI-driven systems now enable detailed mapping of microbial communities, supporting medical research into the microbiome’s role in health and disease, including stroke. These tools can analyze microbiota at high resolution, supporting personalized medicine approaches[6][7].

  • Machine learning models are being developed to personalize dietary interventions based on microbiome composition, genetics, and clinical data[7].

Key Article:

Personalized Nutrition Strategies

Claim: Personalized nutrition, guided by professionals, is important for optimizing brain and gut health after stroke.

Verification:

  • Research supports the development of personalized dietary interventions based on individual microbiome profiles, clinical parameters, and lifestyle factors to optimize stroke recovery and brain health[7].

  • Working with registered dietitians or nutritionists is recommended for tailoring strategies to individual needs[7].

Key Article:

Conclusion

The relationship between diet, the gut microbiome, and stroke recovery is a rapidly evolving field, with promising but still emerging therapeutic strategies. Personalized, anti-inflammatory dietary approaches—especially those modeled after the Mediterranean diet—are currently the most evidence-based recommendations for supporting brain health after stroke. Probiotics and Fecal Microbiota Transplantation (FMT) are promising but require further clinical validation. Advanced technologies are accelerating research in this area, paving the way for more precise, personalized interventions.

For further reading, please see the linked articles above.

Citations

Your brain craves stimulation post-stroke.

Most content doesn’t challenge or inspire.

That can slow mental recovery.

Feed your curiosity with eerie sci-fi & mythic storytelling.

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Thoughts and Insights

The Gut-Brain Axis: Optimizing Nutrition for Cognitive and Emotional Well-being Post-Stroke

Your gut isn't just for digesting food; it's a vital partner in your recovery journey. Listen to your body, and fuel it with kindness!

The Gut-Brain Axis: Optimizing Nutrition for Cognitive and Emotional Well-being Post-Stroke

Recovery after a stroke is a deeply personal journey—one that involves not just physical healing but also a profound recalibration of cognitive and emotional resilience. One of the most crucial yet overlooked aspects of this recovery process is the gut-brain axis, the two-way communication pathway between the gastrointestinal system and the brain. In this article, we explore how nutritional strategies can powerfully influence brain health, mood, and cognitive function in stroke survivors.

Understanding the Gut-Brain Axis in Stroke Recovery

The gut-brain axis is a complex network of biochemical signaling pathways that connect the central nervous system with the enteric nervous system of the gastrointestinal tract. This interaction is mediated through the vagus nerve, immune system, and a thriving community of gut microbiota.

After a stroke, disruptions to this axis can impair mental clarity, increase inflammation, and trigger mood disorders like anxiety or depression. A compromised microbiome can intensify these effects, especially in patients with pre-existing metabolic conditions or compromised digestion.

The Role of Gut Microbiota in Brain Function

Our gut microbiota—trillions of microorganisms living in the digestive tract—play a pivotal role in producing neurotransmitters such as serotonin, dopamine, and GABA. These compounds are critical for emotional regulation, cognitive performance, and motivation.

In stroke survivors, the composition of gut flora often changes, leading to gut dysbiosis—an imbalance that weakens the immune system, increases gut permeability, and contributes to neuroinflammation. This inflammation is not just a local concern; it crosses the blood-brain barrier, affecting memory, focus, and overall mood.

Anti-Inflammatory Nutrition: Rebuilding the Gut-Brain Axis

A powerful way to restore the gut-brain connection is through a targeted anti-inflammatory diet. We recommend prioritizing foods that promote gut flora diversity, strengthen the intestinal lining, and reduce systemic inflammation.

Key Nutrients and Foods to Include:
  • Fermented Foods: Yogurt (with live cultures), kefir, sauerkraut, kimchi, and tempeh support microbiome diversity and aid in neurotransmitter production.

  • Prebiotic-Rich Foods: Garlic, onions, leeks, asparagus, bananas, and oats feed healthy bacteria, enhancing gut health and emotional balance.

  • Omega-3 Fatty Acids: Found in flaxseeds, chia seeds, walnuts, and fatty fish (such as salmon and mackerel), omega-3s reduce inflammation and support brain plasticity.

  • Polyphenols: Blueberries, green tea, olive oil, turmeric, and dark chocolate (minimum 70% cocoa) are rich in antioxidants that protect neurons and enhance cognitive function.

  • Magnesium and B-Vitamins: Leafy greens, legumes, avocados, and seeds help regulate stress and support nerve regeneration.

What to Avoid: Gut-Brain Axis Disruptors

Certain foods and habits sabotage the gut-brain axis and can slow stroke recovery. These include:

  • Ultra-processed foods: High in preservatives, sugars, and unhealthy fats, these disrupt microbial balance and promote inflammation.

  • Artificial sweeteners: Aspartame and sucralose can negatively impact the microbiome and impair mood regulation.

  • Alcohol and excessive caffeine: Both can irritate the gut lining and exacerbate anxiety or insomnia.

  • Low-fiber diets: Fiber is essential for healthy digestion and neurotransmitter production; without it, beneficial bacteria starve.

Post-Stroke Depression and the Microbiome Connection

A significant number of stroke survivors experience post-stroke depression (PSD). Emerging research points to the gut-brain axis as a contributor. Inflammation caused by gut dysbiosis can alter serotonin signaling, decrease BDNF (brain-derived neurotrophic factor), and disrupt cortisol rhythms, all of which play roles in mood regulation.

Incorporating probiotic and prebiotic foods, along with stress-reducing activities like mindful eating, yoga, or meditation, can significantly improve emotional well-being. These interventions restore balance in the gut and positively impact brain chemistry.

Personalized Nutrition Plans: One Size Does Not Fit All

Each stroke survivor has a unique microbiome profile. A personalized nutrition approach—guided by a dietitian experienced in neurological recovery—can identify specific nutrient deficiencies, food sensitivities, and microbial imbalances.

Functional testing, such as comprehensive stool analysis or microbiome sequencing, can provide tailored recommendations to support healing at the gut-brain level. Working closely with a professional ensures dietary changes are both safe and effective, especially when medications are involved.

Hydration and Digestive Health

Hydration plays a critical role in gut motility, nutrient absorption, and cognitive clarity. Dehydration, common in stroke survivors due to mobility issues or medication side effects, can exacerbate fatigue and impair focus.

We recommend:

  • Starting the day with a glass of water

  • Incorporating herbal teas like chamomile, ginger, or peppermint

  • Avoiding sugary beverages and limiting caffeinated drinks to two servings per day

Staying hydrated aids digestion, minimizes constipation (a common post-stroke issue), and supports mental clarity.

Supplements to Consider (With Professional Guidance)

While food should be the first line of defense, certain clinically supported supplements may further enhance gut-brain recovery:

  • Probiotics (multi-strain): To replenish beneficial bacteria

  • L-glutamine: Supports intestinal lining repair

  • Curcumin (with piperine): Potent anti-inflammatory and antioxidant

  • Vitamin D3: Supports immune and cognitive health

  • Lion’s Mane Mushroom: May promote nerve regeneration and neuroplasticity

Always consult with a healthcare provider before starting any supplement, especially when post-stroke medications are involved.

Lifestyle Interventions to Support Nutritional Goals

Nutrition doesn’t act in isolation. Lifestyle habits directly influence the gut-brain connection. We suggest incorporating:

  • Daily movement, even gentle chair-based exercises, to improve digestion and mental well-being.

  • Regular sleep hygiene to restore circadian rhythms and support microbial health.

  • Social connection, which positively influences microbiota diversity and mental health.

Tracking Progress and Staying Motivated

We encourage stroke survivors and caregivers to track symptoms, mood changes, and energy levels in a daily log. Apps like MyFitnessPal, Cara Care, or even a handwritten journal can offer valuable insight into which foods and habits are helping or hindering recovery.

Celebrating small wins—like a better night’s sleep, increased focus, or reduced bloating—can sustain motivation and reveal patterns worth continuing.

Conclusion: Healing the Brain Starts in the Gut

Optimizing the gut-brain axis is not a luxury—it is a necessity in the holistic healing of stroke survivors. Through strategic nutrition, we can empower the brain to recover, the emotions to stabilize, and the body to thrive once again.

Let food become not only fuel but also medicine, and let every meal be a step toward a stronger mind, happier mood, and fuller life post-stroke.

Tips and Techniques: Gut Feelings – Optimizing Your Gut-Brain Axis After Stroke

Gut Feelings – Optimizing Your Gut-Brain Axis After Stroke

Okay, so how do you actually do this gut-brain thing? Here are some practical tips to get you started:

  • Embrace the Rainbow (of Fruits and Veggies): Different colored fruits and vegetables contain different types of fiber and prebiotics (food for your good bacteria). Aim for a wide variety to feed your gut's diverse population.

  • Fiber is Your Friend: Fiber-rich foods like whole grains, beans, lentils, fruits, and vegetables promote healthy digestion and feed beneficial gut bacteria. Slowly increase your fiber intake to avoid digestive discomfort.

  • Consider Probiotic-Rich Foods: Yogurt (look for ""live and active cultures""), kefir, sauerkraut, kimchi, and kombucha are all great sources of probiotics.

  • Limit Processed Foods, Sugar, and Artificial Sweeteners: These can disrupt your gut microbiome and promote inflammation. This isn't just about avoiding them altogether, but being mindful of how frequently these foods are part of your day to day life.

  • Stay Hydrated: Water is essential for healthy digestion and gut function.

  • Manage Stress: Stress can negatively impact your gut microbiome. Practice relaxation techniques like deep breathing, meditation, or gentle exercise to manage stress levels.

  • Move Your Body: Physical activity can also promote a healthy gut microbiome. Even gentle movement, like walking or stretching, can be beneficial.

  • Talk to a Professional: Work with a registered dietitian or nutritionist to develop a personalized eating plan that supports your gut-brain axis and overall recovery. They can help you identify any food sensitivities or intolerances and create a plan that meets your specific needs.

  • Consider Supplements, Carefully: Speak with your doctor about adding a quality probiotic or prebiotic supplement. They may have suggestions and specific types or brands that work well for your specific needs.

  • Track Your Progress: Keep a food journal and make notes about how you feel and the correlation to gut issues. This may help you and your medical team determine any harmful trigger foods that you should avoid.

  • Chew Your Food Properly: This sounds like an obvious recommendation, but many people do not chew their food for the appropriate amount of time. When food is chewed well, it reduces the workload of the gut, and improves nutrient absorption.

Example Meal Plan Ideas

  • Breakfast: Oatmeal with berries, nuts, and a dollop of yogurt.

  • Lunch: Salad with grilled chicken or fish, a variety of colorful vegetables, and a vinaigrette dressing.

  • Dinner: Baked salmon with roasted vegetables (broccoli, carrots, sweet potatoes).

  • Snacks: Apple slices with almond butter, a handful of nuts, or a small container of yogurt.

Silly Humor Section: Gut-Busting Giggles

  • Why did the probiotic cross the road? 

    • To get to the other SIde of your digestive system!

  • I told my gut a joke. 

    • It intestinaly laughed!

  • What do you call a nervous stomach? 

    • Butterfly’s in your stomach!

A Stroke Survivor Joke

  • I tried to explain the gut-brain axis to my dog, but he just gave me a blank stare. I guess he's got other things on his mind… like squirrels!

Dig Deeper!

Want to learn more about the gut-brain connection and how it affects stroke recovery? Check out these resources:

1. The Gut-Brain Connection: How it Works and the Role of Nutrition

  • The Brain Balance Centers blog discusses how science is uncovering the connection between the brain and the gut, emphasizing the important role nutrition plays in how we feel and function. The organization’s nutrition program, Balance 360, is designed to cultivate good gut health because of this gut-brain connection, particularly for children with developmental challenges[3].

  • Read more

2. "Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain--for Life" by David Perlmutter, MD

  • This book explores the interplay between intestinal microbes and the brain, explaining how nurturing gut health can improve brain function and potentially prevent or treat neurological diseases. Dr. Perlmutter outlines how the microbiome develops, how it can become unhealthy, and offers dietary recommendations to improve gut ecology[6][4].

  • Read more

3. Healing The Gut Can Reduce Long-Term Impact Of Stroke (Texas A&M Research)

  • Recent research from Texas A&M University demonstrates that healing the gut after a stroke can significantly reduce long-term cognitive impairment. Treatments targeting the gut, such as IGF-1 and stem cell transplants, have shown promise in improving stroke outcomes by reducing inflammation and repairing gut structures, which in turn helps preserve brain function[2][7].

  • Read more

4. Gut Microbes May Improve Stroke Recovery (UK College of Medicine)

  • Research published in the Journal of Neuroscience indicates that gut microbes, particularly those producing short chain fatty acids, can help protect brain cells from inflammation after a stroke. Supplementing these fatty acids may improve stroke recovery, highlighting the role of the microbiome in brain health and recovery[5].

  • Read more

5. Stroke Breakthrough Takes Aim at the Gut (New Atlas)

  • New research shows that changes in gut bacteria after a stroke can increase brain inflammation, but restoring beneficial gut substances can help reduce this inflammation and improve recovery. The study underlines the importance of the microbiota-gut-brain axis in stroke outcomes and suggests that targeting the gut could be a therapeutic strategy for reducing neuroinflammation after stroke[7].

  • Read more

Summary:
The resources above confirm that the gut-brain connection plays a significant role in stroke recovery. Both scientific research and popular literature highlight how gut health influences brain inflammation, cognitive function, and recovery outcomes after stroke. Interventions aimed at improving gut health—through nutrition, microbiome support, or targeted therapies—are increasingly recognized as important strategies for enhancing recovery and reducing long-term impacts of stroke.

Citations:

AI-Generated Writing and Art: Creative Connections

AI-Generated Poem: Gut Symphony

A garden within, a vibrant hum, Where microbes dance, and worries numb. A highway paved with mindful bites, Connecting tummy to brain's bright lights.

The Reluctant Chef

When a stroke threatened to rob retired engineer Luke of his independence, he discovered that the connection between gut and brain could rebuild more than just neural pathways.

The Reluctant Chef

Luke stared at the kitchen as if deciphering an unfamiliar blueprint. At sixty-three, after forty years of marriage with Abby handling all meal preparation, the retired bridge engineer now faced his most daunting design challenge. The stroke six months ago had compromised his left side—his fingers unreliable instruments, his speech occasionally faltering, his meticulous mind now frustratingly prone to fog.

"Everything's prepped and labeled," Abby said, pressing a gentle kiss to his forehead. Her calm exterior barely masked her concern about leaving him while she cared for her mother. "Remember Dr. Patel's explanation about the gut-brain axis? Those fermented foods aren't just healthy—they're rewiring your neural pathways."

Luke nodded, the tightness in his throat making speech difficult. Throughout his career, he'd approached each problem with precision and confidence. Now, distinguishing between kimchi and sauerkraut seemed more complex than calculating load-bearing tolerances.

Alone the first morning, Luke studied the kitchen like a worksite, eyes narrowed in concentration. He opened his laptop one-handed, creating a meticulous flowchart: "Breakfast: kefir (beneficial bacteria → reduced inflammation → improved cognitive function) + blueberries (antioxidants → neural protection) + omega-3 rich walnuts (synaptic plasticity → memory enhancement)."

His first attempts were disasters. The smoothie he attempted splattered across his shirt when the blender lid popped off. The next day's eggs stuck to the pan despite careful temperature calculations. By day three, as a jar of carefully cultured kombucha shattered on the tile floor, frustration overwhelmed him.

"Worthless," he muttered, his speech slurring with emotion as he slumped at the kitchen table. His hands—once steady enough to draft the county's main bridge—trembled uncontrollably. He reached for his phone to admit defeat to Abby, then hesitated. Through their nightly calls, he heard the exhaustion behind her encouraging words. She was carrying enough already.

Instead, he called Sam, his former project manager who had reached out weekly since the stroke, despite Luke's frequent rebuffs.

"Cooking? You?" Sam didn't hide his surprise. When he arrived an hour later, he didn't bring pity—just a practical apron with adaptive Velcro closures.

"Marjorie had her stroke during our anniversary dinner," Sam explained, demonstrating how to steady a cutting board with a silicone mat. "The diet changes were her idea—said if she had to relearn walking, I had to relearn cooking. Those gut-brain foods made a measurable difference in her recovery curve."

Luke raised an eyebrow at the engineering terminology. "Measurable how?"

"Tracked it like a project timeline," Sam grinned, helping Luke position his good hand on the knife. "Reduced brain fog within three weeks. Improved mood stability by month two. Consistent sleep patterns established by month three."

They approached cooking with engineer's logic—breaking recipes into sequenced steps, modifying tools for one-handed efficiency, developing workarounds for each limitation. When Luke's hand cramped while chopping garlic, Sam demonstrated a rocking motion with the knife rather than taking over.

Progress came in measurable increments. By day five, Luke successfully assembled a breakfast without spillage. By day ten, he'd developed a methodology for fermenting his own yogurt, tracking acidity and temperature with the same rigorous attention he'd once given to structural calculations.

During their evening calls, Abby noticed subtle changes. "Your speech is clearer today," she observed on day twelve. "Less searching for words."

Luke hadn't quantified it himself, but realized she was right. The dense mental fog that typically descended by afternoon had lifted earlier each day. His sleep quality improved according to his fitness tracker data. Most surprisingly, the persistent anxiety that had gripped him since the stroke had loosened its hold.

"The gut-microbiome communication pathway appears effective," he told her with the hint of dry humor that had been absent for months. "Further experimentation warranted."

When Abby returned two weeks later, exhausted from caregiving, she paused in the kitchen doorway. Where once there had been sterile precision, there now existed purposeful chaos—fermentation jars bubbling on the counter, each labeled with acidity readings and dates; herb plants under grow lights; a whiteboard tracking correlations between specific ingredients and cognitive improvements.

Luke stood at the stove, his affected hand supported in an adaptive mitt, stirring a fragrant fish stew rich with turmeric and ginger.

"Welcome home," he said, the words clearer than they'd been in months. "Dinner's at optimal temperature."

Tears welled in Abby's eyes. For months she'd watched him retreat from the world, defining himself by his limitations.

"Luke," she whispered, "what happened here?"

He smiled, the asymmetry of his face somehow making his expression more profound. "Applied engineering principles to nutritional neuroscience," he said, ladling the golden stew into bowls. Then more softly, "Discovered that rebuilding a brain starts with nourishing the gut."

As they sat together, sharing the meal he had created—his first gift to her after months of receiving her care—they both understood that healing wasn't just happening inside his body. It was happening in the space between them, in the reclaiming of balance in their relationship, bite by nourishing bite.

Remember, you're not alone on this journey! Keep fighting, keep learning, and keep nourishing your body and mind.

Your friend,

Chuck

Important Considerations:

  • Disclaimer: This newsletter is for informational purposes only and should not be considered medical advice. Always consult with your doctor or other qualified healthcare provider before making any changes to your diet or treatment plan.

  • Personalization:. I encourage readers to consult with healthcare professionals for personalized guidance. "

 

That's it for this week's newsletter, dear Stroke Warriors! Keep in mind,life doesn't stop after a stroke – it's an opportunity to embrace new experiences. Remember, you are not alone on this journey, you are strong, and together, we can overcome any challenge.. Embrace your rehabilitation with determination, and know that progress is within reach.

Disclaimers

Disclaimer:  

The information provided in this newsletter is for general informational purposes only and is not intended to constitute professional advice.

Medical Disclaimer:  

The content shared in this newsletter is not intended to be a substitute for professional medical advice.

Accuracy Disclaimer:  

While we make every effort to provide accurate and up-to-date information, the content in this newsletter may contain errors, omissions, or inaccuracies.

We hope you found the information valuable and informative.

With the assistance of AI, I am able to enhance my writing capabilities and produce more refined content.  

This newsletter is a work of creative AI, striving for the perfect blend of perplexity and burstiness. Enjoy!

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Keep fighting and stay resilient!

With warm regards,

Chuck and the Stroke Warrior Team

P.S. If you missed last week's newsletter on “Issue #91: (New) Assistive Tech That’s Helping Stroke Survivors Walk Again!”  you can catch up here:  

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